https://www.moehlelab.org/publications daily 0.75 2025-11-13 https://www.moehlelab.org/get-started daily 0.75 2020-10-06 https://www.moehlelab.org/team daily 0.75 2025-11-13 https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/50dc2a62-faeb-4126-bbac-0ae3c1be729a/IMG_5177+%282%29.jpg The Team - Undergraduate Research Assistant Ryan Dorsey Ryan joined the lab in summer of 2025. He is a third-year kinesiology major at UF. https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/0ecc816a-343d-488d-a116-29124af3a628/original-19B9E016-A76F-4639-A37B-B7A80D8C5D3D.jpeg The Team - Graduate Research Assistant Camille Preston Camille joined the lab in the summer of 2025. Her primary research goal is understanding the microcircuitry of neurons affected in GNAL-linked dystonia. In her spare time she likes to work out, play the flute, and travel. https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/339f46a6-5151-4e96-af4e-5d0156d0f1cb/BB.jfif The Team - Postbac Barbara Balsamo, B.S. Barbara joined the lab in the spring of 2023 as an undergraduate research assistant. She then went on to participate in the Summer Neuroscience Internship Program and is now working in the lab as a postbac through the Gator Aid Program. https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/c4903c9a-3a8a-4ee9-a665-8f514320706b/Todd.jpg The Team - Postdoctoral Fellow Todd Sahagian, Ph.D. Dr. Sahagian joined the lab in Summer 2025. He is interested in the balance between excitation and inhibition mechanisms in cellular and synaptic networks and how these components integrate into larger cellular systems in states of good health and in various health conditions. Aside from his work in the laboratory, Todd enjoys running, biking, cooking, and spending time with his loved ones. https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/3da0d125-2902-4ba8-aabc-820ae6c26baf/2023_11_09_Jessica+Reinhardt_NG8751.jpg The Team - Graduate Research Assistant Jessica Reinhardt, M.S. Jessica joined the lab in March of 2024. Outside of the lab she is a sports fan and avid soccer player. https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/6599ae3d-2c7c-457a-abd8-3a4520999672/r_staab_tylers_decent.jpg The Team - Volunteer Research Assistant Rick Staab Rick joined the lab as a volunteer in spring of 2024. He is the Founder and President of Tyler’s Hope for a Dystonia Cure. https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/9c567915-79bb-44a1-b9af-28ef7649e94b/GB.jpg The Team Undergraduate Research Assistant Giuseppe Balsamo Giuseppe joined the lab in Spring of 2025 and is majoring in chemical engineering. https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/d79ca570-6ac0-4845-ae47-7e1f7158711b/IMG_6010.png The Team - Undergraduate Research Assistant Alexander Hanson Alex joined the lab in Summer of 2024 and is a senior Behavioral & Cognitive Neuroscience major. He is currently completing an honor’s thesis in the Moehle lab which focuses on neural activity during reach-to-grasp behaviors in cerebellar Gnal knockout animals. https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/698e4db3-db64-43c4-9ab7-64231b228644/IMG_5177.jpg The Team - Undergraduate Research Assistant Mary Kim Mary joined the lab in summer 2025 and is a double-major in behavioral and cognitive neuroscience and nutritional sciences. https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/c145710f-04e2-4f0a-9781-23959368f5ac/Gavin.jpg The Team - Undergraduate Research Assistant Gavin Emdur Gavin joined the lab in Fall of 2024 and is a third year biology major. Outside of the lab he plays in the marching band. https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/3304fedf-d616-42d7-81b0-e2432689086d/Ignacio+Gallardo.jpg The Team - Graduate Research Assistant Ignacio Gallardo Ignacio joined the lab in March of 2023. He is interested in understanding the cellular and molecular mechanisms underlying various neurodegenerative diseases to pave the way for novel therapeutics. In his free time, Ignacio enjoys working out, traveling, and playing the drums. https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/43f23401-c096-4ddf-845f-998f981e326b/IMG_0213.jpg The Team - Postdoctoral Fellow Nicole Chambers, Ph.D. Dr. Chambers joined the lab in November of 2021. She is interested in the neural correlates of motor and non-motor symptoms of movement disorders. Outside of the lab she enjoys hiking, kayaking, and playing the clarinet and piano. https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/1ec138f3-8e84-4751-8ae1-a8c0f663bcbe/MSM.jpg The Team - Principal Investigator Mark Moehle, Ph.D. Dr. Moehle joined the Department of Pharmacology & Therapeutics in August 2020 to establish his independent lab. https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/29467a55-dec7-4c14-bc53-7412a8c7f2e5/IMG_5177+%281%29.jpg The Team - Undergraduate Research Assistant Kate De Peralta Kate joined the lab in the Summer of 2025 and is a third year Health Science Major. https://www.moehlelab.org/research-projects daily 0.75 2020-10-06 https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/1602016424732-9Z0ERSQKW5MK52AGYP3K/Cerebellum.png Research Projects - Pilot Project: Dyt1 Dystonia Mutations in Dyt1 are causative for dystonia. Recent evidence suggests that loss of this gene in the cerebellum drives dystonic phenotypes. We aim to understand how muscarinic modulation can alter these cerebellar phentotypes for symptomatic benefit in this form of dystonia. https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/1602014053917-NU7VBR613D1YWI2XMKAL/Mechanism.png Research Projects - Biology of the M4 mAChR in the Basal Ganglia Several mechanisms for how activation of the M4 muscarinic acetylcholine receptor influences the basal ganglia have been previously identified. We continue to explore how M4 can influence the basal ganglia. Current effort is focused on understanding the role of M4 in modifying cholinergic neuron activity and acetylcholine release. https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/1602013733202-Z8CCKX0AQTOT6RP7IYD9/GNAL.jpg Research Projects - GNAL Linked Dystonia Mutations in GNAL encoding the G protein alpha subunit Galpha(olf) are causitive for dystonia. Using novel mouse and viral models of this form of dystonia, we are performing multidisciplinary experiments to understand how dystonia occurs and which brain region(s) drive dystonia https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/1602014930094-20DNSA1N5LF3EPX2UIWD/LBD.png Research Projects - Lewy Body Dementia Lewy Body Dementia is part of a family of disorders caused by the accumulation of alpha-synuclein into pathological aggregates. In this project we aim to understand how pathological alpha-synuclein alters neuronal physiology and circuitry, and how certain neuromodulatory GPCRs can reverse these changes. https://www.moehlelab.org/techniques daily 0.75 2020-10-08 https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/1602168460161-YZ6Q2SCVW5XVQOI31LZP/ephys+technique.png Techniques - Electrophysiology We use whole cell patch clamp electrophysiology and field techniques to examine a number of components of individual neurons, synaptic strength, and neurotransmitter release. The Moehle Lab currently has 2 complete electrophysiology rigs capable of most ex vivo electrophysiology techniques. https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/1602172673053-ILJ7SXB41CE3XXG8WULI/Dreadd.png Techniques - DREADDs Like optogenetics, designer receptors exclusively activated by designer drugs (DREADDs) can be used to activate or inhibit specific neurons or groups of neurons. Instead of using light, these modified receptors are activated by inert small molecules. https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/1602168917154-VC5ZERW5X3S0Z5OX1O8B/behavior.png Techniques - Behavioral Monitoring To examine the consequences of pharmacological manipulation or the consequence of genetic mutations, we use a number of behavioral techniques to fully characterize the motor, gait, and cognitive behaviors of mice. https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/1602171560249-6IB9H2RGRXQ873VG73DQ/opto.png Techniques - Optogenetics Optogenetics allows for the activation or silencing of specfic neurons or pathways using specific wavelengths of light. This can be used in vivo to study the role of individual neurons or brain nuclei on behavior or ex vivo in electrophysiology. https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/1602170362903-3A296HYLPBUJSHYYWEU6/Biochem.png Techniques - Biochemistry and Molecular Biology We use a number of molecular and biochemical techniques to understand the physiological changes in our different model systems. These include IHC, western blotting, RT-PCR, PCR, viral mediated gene transfer, design of AAV vectors, and RNAscope. The Moehle Lab has access to a number of high end microscopes and other imaging equipment https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/1602168719977-OMJLMNXK5U8T92FWDXZW/biosensor.png Techniques - Fiber Photometry We use fiber photometry to examine neurotransmitter release and neuronal activity in awake behaving animals, and directly tie these events to changes in mouse behavior. We currently have an Rz10x Fiber Photometry system from TDT capable of recording from 2 animals in 2 colors simultaneously. https://www.moehlelab.org/contact daily 0.75 2025-04-10 https://www.moehlelab.org/home daily 1.0 2020-10-08 https://www.moehlelab.org/mark-s-moehle-1 daily 0.75 2022-09-02 https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/d853cb43-97af-44d3-b98e-dffa003d9d6a/MSM.jpg Mark S. Moehle - Mark Moehle, Ph.D. Dr. Moehle joined the Department of Pharmacology & Therapeutics in August 2020 to establish his independent lab. Before coming to the University of the Florida, he completed a postdoc in the lab of P. Jeffrey Conn at Vanderbilt University and graduate school in the lab of Andrew West at the University of Alabama at Birmingham. https://www.moehlelab.org/lab-alumni daily 0.75 2025-11-13 https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/219b0f9b-834f-4236-8547-623714d68b3b/DH.jpg Lab Alumni https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/38046ff2-8b21-456e-85b1-ef27bafa9788/Evan.jfif Lab Alumni https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/6da379a9-2a1f-4018-b00c-da347229f69c/IMG_2667.JPG Lab Alumni https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/bc99d87f-57a7-433f-b0cb-9de0917be493/AnikaHeubergerHeadshot.jpg Lab Alumni https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/a0ab03fc-5bc3-4347-8f97-c19cbe66ed90/TC.png Lab Alumni https://images.squarespace-cdn.com/content/v1/5f7c80b086f4bd0ad4b34ed0/9e38fd10-52fa-4bed-a3c6-b5d2fd21eb2a/IMG_8570.jpg Lab Alumni 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